منابع مشابه
Acyclic retinoids and cancer chemoprevention
-___ Abstract Human trials of cancer chemoprevention employing antitumor promoter retinoids are currently progressing worldwide and are targeting mainly skin, lung, uterine cervix or breast cancers. Although the inhibitory effects of various synthetic retinoids on experimental cancers and tumor-derived cell lines are promising, several problems with adverse effects such as mucocutaneous disorde...
متن کاملClinical trials with retinoids for breast cancer chemoprevention.
Retinoids have been studied as chemopreventive agents in clinical trials due to their established role in regulating cell growth, differentiation and apoptosis in preclinical models. Experimental evidence suggests that retinoids affect gene expression both directly, by activating and/or repressing specific genes, and indirectly, by interfering with different signal transduction pathways. Induct...
متن کاملSystemic retinoids: chemoprevention of skin cancer in transplant recipients.
Solid organ transplant recipients (OTRs) have an increased incidence of skin cancer, resulting in significant morbidity and mortality post-transplantation. Chemoprevention strategies are focused on reducing and delaying the development of skin cancer in these patients. Although systemic retinoids are widely used in OTRs, few randomized controlled trials have been performed. Limited data suggest...
متن کاملMolecular mechanisms of chemoprevention and therapy of cancer by retinoids.
Chemoprevention is the use of noncytotoxic therapeutic intervention at the early stages of carcinogenesis against the development and progression of mutant clones to invasive cancer. Retinoids are the most extensively studied and one of the most prominent groups of chemopreventive agents to reach clinical trials. Acute promyelocytic leukemia is the first human malignancy that is successfully tr...
متن کاملThe Molecular Basis of Retinoids’ Use in Breast Cancer Chemoprevention
Whereas encouraging, interpretations of available data regarding retinoids’ effectiveness in breast cancer chemoprevention, e.g. [5,7] fail to address pivotal molecular aspects concerning their employment in clinical trials. The rationale for using retinoids in chemoprevention is primarily based on their ability to coordinately regulate differentiation, proliferation and apoptosis. The discover...
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ژورنال
عنوان ژورنال: Nippon Eiyo Shokuryo Gakkaishi
سال: 1993
ISSN: 1883-2849,0287-3516
DOI: 10.4327/jsnfs.46.1